Rupert Sheldrake, a fellow of the Institute of Noetic Sciences, is a biologist who has spent many years exploring and developing an alternative view of evolution one in which "formative causation", "morphogenetic" or "mental" fields play a decisive role. Sheldrake is also a scientist who devotes time regularly to the practice of prayer and exploration of its efficacy. How did a scientist come to be so interested in prayer, and how does he reconcile this with his scientific training? In December last year , IONS editor Christian de Quincey visited Sheldrake in his London home to talk about prayer and science. The following article is based on that interview.